Nucleic Acid Synthesis in Mustard Gas-treated E. Coli B
نویسنده
چکیده
Following exposure to dilute aqueous solutions of mustard gas, suspensions of E. coli B do not produce DNA although PNA is formed in nearly normal amounts. When the treated cells are infected with virus T(2), DNA is synthesized and RNA is not. The DNA formation continued after the virus titer reached a maximum.
منابع مشابه
Inactivation of Viruses and Cells by Mustard Gas
The action of mustard gas on six animal, one plant, and two bacterial viruses; also on bacteria, yeast, and the pneumococcus-transforming principle has been studied. The viruses include Newcastle's disease of chickens, equine encephalomyelitis (Eastern strain), feline pneumonitis (Baker), rabbit papilloma (Shope), fixed rabies, rabbit myxoma, tobacco mosaic, T(2)r(+) phage of E. coli B, and a S...
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1. A quantitative study was made of the relationship between survival of colony-forming ability in Escherichia coli strains B/r and B(s-1) and the extents of alkylation of cellular DNA, RNA and protein after treatment with mono- or di-functional sulphur mustards, methyl methanesulphonate or iodoacetamide. 2. The mustards and methyl methanesulphonate react with nucleic acids in the cells, in the...
متن کاملThe reaction of mustard gas with nucleic acids in vitro and in vivo.
Mustard gas [di-(2-chloroethyl) sulphide] and analogous alkylating agents produce a wide range of biological effects (cf. review by Boyland, 1948). Some ofthese effects, such as induction ofmutations (Auerbach & Robson, 1946) and interference with mitosis and chromosome breakage (Darlington & Koller, 1947), stimulated interest in the reactions of alkylating agents with deoxyribonucleic acid. Pr...
متن کاملThe Formation of Bacterial Viruses in Bacteria Rendered Non-viable by Mustard Gas
E. coli B and Staphylococcus muscae rendered non-viable by aqueous solutions of mustard gas at pH 7.5 to 8 can still produce phage.
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ورودعنوان ژورنال:
- The Journal of General Physiology
دوره 34 شماره
صفحات -
تاریخ انتشار 1951